Lillian Wilson

The Autoimmune Brain by David S. Younger

Discover the connection between immunity and the brain and practical strategies for improving brain health with ‘The Autoimmune Brain.’

The Autoimmune Brain

The book has received 4.6 ⭐️ from readers on Amazon.

In today’s world, countless individuals grapple with perplexing brain health issues, ranging from depression and attention problems to anxiety, fatigue, and chronic pain. Despite seeking help and trying various treatments, they’re caught in a cycle of frustration. Some even experience sudden severe psychiatric symptoms.

As a neurologist, Dr. David S. Younger observed these struggles firsthand. His book ‘The Autoimmune Brain’ aims to bridge the gap in understanding the profound link between autoimmunity and brain health. In this review, we’ll explore how the book addresses these complex issues, offering fresh insights into diagnosing and addressing the intricate relationship between autoimmunity and brain health.

Author’s background

Dr. David S. Younger, a globally acclaimed neurologist, has dedicated the last 30 years to studying conditions prompted by infections and autoimmunity.

Dr. David S. Younger (r)

Possessing extensive expertise in neurology and public health, he specialises in employing immunotherapy for the treatment of specific neurological disorders in both children and adults. Dr. Younger owns an extensive experience in peripheral neuropathy and has authored several books alongside over 250 articles.

What is the book about?

‘The Autoimmune Brain’ addresses the challenges faced by numerous individuals experiencing a range of brain health issues such as depression, anxiety, fatigue, chronic pain, and more, without finding effective solutions. These patients often encounter dismissive attitudes from doctors or inappropriate treatments. Dr. Younger offers a groundbreaking approach to diagnosis and treatment, aiming to help readers identify the underlying causes of their symptoms and guide them toward healing.

In this book, Dr. Younger establishes a correlation between prevalent brain health symptoms and alterations in the immune system, with a particular focus on bacterial, viral, and parasitic infections. He presents research that illuminates the significant roles of traumatic stress, encompassing both physical and emotional forms, in initiating ailments and brain health symptoms. Remarkably, shifts in personality, behaviour, coping mechanisms, and emotional states can serve as early indicators of latent health issues in other areas of the body.

The book sheds new light on treating and alleviating various conditions, including Alzheimer’s disease, anxiety, autism, chronic pain, depression, Lyme disease, and more. Dr. Younger empowers readers to discover novel explanations for the origins of these disorders by linking typical symptoms of brain health to changes in the immune system triggered by infections.

Table of contents

  • Preface
  • Preface to the Paperback Edition
  • Abbreviations
  • Introduction
  • PART I: Understanding I-Cubed
  • 1. The Basics of Brain Health and Autoimmunity.
  • 2. How the Brain Develops
  • 3. Is My Problem Neurological or Psychiatric?
  • 4. Own Your Genetics
  • PART I: TAPES: A 5-Step Action Plan
  • 5. Test for an Autoimmune Disturbance
  • 6. Apply Immune-Modulatory and Pain Therapy.
  • 7. Participate in Therapies that Address Stress and Mental Health Concerns
  • 8. Eat and Exercise to Restore Brain Health and Reset the Immune System
  • 9. Survey Your Environment for Toxic Exposures
  • PART III: Autoimmune Diseases That Affect Brain Health
  • 10. Developmental Disorders Affecting Children and Teens
  • 11. Sore Throats Lead to Sore Heads: On the Lookout for PANDAS and PANS
  • 12. The Gut-Brain Connection: Celiac Disease and Beyond
  • 13. Concussions Leave Their Mark
  • 14. Neuroendocrine and Mast Cell Activity Determine How You Respond to Stress
  • 15. Porphyria: A Misdiagnosed Neurogenetic Disorder
  • 16. Chronic Fatigue Syndrome: Relief for Exhausted Patients
  • 17. Lyme Disease: The Great Imitator or the Great Trigger?
  • 18. Spondyloarthropathy: I-Cubed and Genetically Predetermined Joint Diseases
  • 19. Autoimmune Encephalitis: A Brain on Fire
  • 20. Alzheimer’s Disease and Other Dementias: Autoimmune Insights
  • 21. The Surprising Link between COVID-19 and I-Cubed
  • 22. Putting It All Together to Resolve Your Health
  • Notes

Key takeaways from ‘The Autoimmune Brain’

1Immune-brain connection and why inflammation can cause cognitive impairments

In his exploration of brain health, Dr. Younger delves into the intricate interplay between the immune system and the brain. Autoimmune reactions, stemming from immune response disruptions influenced by genetics, microbiome, and body burden, can affect brain function before physical symptoms appear. This autoimmune response, which affects one in seven American men, underscores the importance of a low-inflammatory diet in regulating inflammation and restoring bodily function. The interaction between the immune system and the brain also highlights the role of the blood-brain barrier (BBB), which can be compromised by autoimmune-induced inflammation, leading to cognitive challenges. Dr. Younger’s insights emphasise understanding the link between inflammation and brain health as a foundation for a well-being journey, offering strategies from dietary adjustments to lifestyle changes to mitigate autoimmune reactions, reduce inflammation, and promote optimal brain function.

2By overcoming stress, we can improve brain health

Dr. Younger’s revelations bring a new twist to our understanding of how our brains handle stress. The author cites studies that show that our ability to bounce back from tough times is not just about having a strong mind – it is also about how our bodies respond to stress. Imagine stress as a puzzle, and our bodies have unique pieces that help us solve it better. These puzzle pieces are like soldiers that fight against stress, and they are actually parts of our immune system. This means that even when our mind says, ‘I can do it,’ our body’s soldiers play a vital role too. Dr. Younger recommends meditation as a way to boost brain resistance and ease stress. When you meditate, your brain learns to relax, focus better, and handle emotions like a pro. Science has shown that meditation can even change your brain’s structure for the better, making it stronger and more resilient.

3Exercise and proper diet are the two fundamental pillars for better brain health

In the chapter ‘Eat and Exercise for Brain Health and Immune System Reset,’ the author underscores the vital significance of diet and exercise in maintaining brain health. Dr. Younger highlights the power of an anti-inflammatory diet, like the Mediterranean-DASH Intervention for Neurodegenerative Delay diet, which prioritises plant-based foods rich in antioxidants to combat inflammation and oxidative stress. Healthy fats, particularly omega-6 and omega-3 polyunsaturated fatty acids, are also spotlighted for their cognitive and synaptic benefits.

The book further emphasises the symbiotic relationship between exercise and brain health. Regular physical activity not only enhances neural plasticity and cognitive function but also promotes a positive mood, lowering the risk of depression and anxiety. Importantly, Dr. Younger highlights that exercise’s benefits are accessible at any age, even when initiated in midlife. The interplay of diet and exercise as potent instruments for enhancing brain health emerges as a central revelation in the quest for overall well-being.

Strengths and weaknesses, according to readers’ reviews


  • Written by an experienced healthcare provider, the book makes a highly trusted and credible source of knowledge.

  • Provides actionable advice on addressing brain health issues.

  • Offers real-world examples of patients and their paths to healing, making complex concepts relatable.


  • Extensive use of medical terminology makes the reading experience challenging, especially for readers new to the topic.

  • The section with dietary recommendations lacks depth and provides only surface-level information regarding the role of nutrition in handling autoimmune disorders.

  • While the book touches on lesser-known conditions, the depth of coverage might leave some readers craving more comprehensive insights into these topics.

Best quotes from ‘The Autoimmune Brain’

“…new findings provide compelling evidence for the role that inflammatory and post-infectious auto-immune processes play in our ability to handle stress, including PTSD. In fact, researchers have found that our ability to be resilient has more to do with biology than psychology.”
“…autoimmune disorders may be viewed as “autoimmune errors” committed by your immune system. Recovery from autoimmune disorders depends on your immune system’s ability to correct its own error. In some autoimmune disorders, this occurs in as little as a few weeks, while others take longer. Immune therapy reduces ongoing injury when the organs self-correct the autoimmune error.”
“There are exciting new technological tools, referred to as eHealth options, that have been proven to reduce and manage stress, reduce depression, track sleep, and teach impulse control for those with obsessive compulsive disorder. Scientific studies focusing on eHealth has grown rapidly over recent years with several controlled trials in the field of anxiety disorders, mood disorders, and behavioral medicine. Two meta-analyses found that eHealth interventions could both reduce and prevent depression and anxiety.”

Final takeaway

‘The Autoimmune Brain’ by David S. Younger sheds light on the connection between the immune system and brain function as well as underscores various strategies for optimal cognitive well-being. The book serves as an essential guide for anyone seeking to comprehend, address, and improve their brain health within the framework of immune response and autoimmunity. Whether you are an individual on a journey to reclaim your well-being or a healthcare provider in search of actionable insights, Dr. Younger’s book offers a unique and comprehensive perspective on the complex interplay between our bodies, minds, and immune systems.

Where to buy

You may purchase ‘The Autoimmune Brain’ on Amazon at the best price. It is available in paperback, hardcover, audio and Kindle versions, so you may choose an option that appeals to you the most.

Healthypedia FAQ

Dr. Younger supports his insights with scientific and clinical evidence, making the book a well-rounded resource backed by credible research.

Yes, ‘The Autoimmune Brain’ presents a 5-step action plan called TAPES, offering readers actionable strategies to test for autoimmune disturbances, apply immune-modulatory therapies, address stress, adopt a brain-healthy diet, and survey environmental factors.

‘The Autoimmune Brain’ covers brain health issues across all age groups, from children to seniors, making it relevant for individuals of all ages.

Yes, ‘The Autoimmune Brain’ discusses dietary strategies, such as the anti-inflammatory Mediterranean-DASH Intervention for Neurodegenerative Delay diet, to combat inflammation and support brain health.

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