Lillian Wilson

The Hungry Brain by Stephan J. Guyenet

The Hungry Brain offers a scientifically-grounded exploration of the brain's pivotal role in appetite regulation and weight management.

The Hungry Brain

The book has received 4.06 ⭐️ on GoodReads.

In today’s world, where obesity rates are on the rise, and countless diets and weight loss solutions flood the market, it’s easy to become overwhelmed by the sheer volume of information available. Amid this cacophony of advice and strategies, The Hungry Brain by Stephan J. Guyenet emerges as a refreshing and scientifically grounded exploration of the complex relationship between our brains, genetics, and eating habits.

In this book review, we will delve into the key insights and takeaways from The Hungry Brain, offering a glimpse into the wealth of knowledge it provides on the topic of weight management.

Author’s background

Stephan J. Guyenet, Ph.D., is a renowned obesity researcher and health author who combines insights from neuroscience, physiology, evolutionary biology, and nutrition to provide insights and remedies for the worldwide issue of excess weight.

Stephan J. Guyenet (r)

He completed his undergraduate studies in biochemistry at the University of Virginia and earned a doctoral degree in neurobiology from the University of Washington. Dr. Guyenet is also the creator of the well-received health platform known as Whole Health Source and is a frequent presenter on subjects related to obesity, metabolism, and dietary science.

What is the book about?

The Hungry Brain by Stephan J. Guyenet explores the intricate connection between our brains, genetics, and chemical processes, shedding light on how they profoundly influence our eating habits. Through meticulous research involving humans and laboratory rats, Guyenet investigates the complex factors shaping our dietary choices.

The book delves into the intriguing question of why our brains seem wired to promote weight gain and health problems. Guyenet suggests that these mechanisms evolved to support our survival, well-being, and reproduction in a vastly different ancient environment. He draws parallels with contemporary hunter-gatherer societies, demonstrating how instincts that once served us well have become problematic in today’s food-rich environment, leading to conditions like overeating and obesity.

Guyenet introduces the concept of ‘evolutionary mismatch,’ where once-beneficial traits become problematic in a different context, explaining the prevalence of chronic disorders in affluent societies. He emphasises the brain’s pivotal role in regulating appetite, eating behaviour, physical activity, and body fatness. Despite the complexity often found in academic literature, Guyenet strives to make this knowledge accessible, offering insights into specific brain systems that drive our eating behaviours and general brain function.

Table of contents

  • Introduction
  • 1. The Fattest Man on the Island
  • 2. The Selection Problem
  • 3. The Chemistry of Seduction
  • 4. The United States of Food Reward
  • 5. The Economics of Eating
  • 6. The Satiety Factor
  • 7. The Hunger Neuron
  • 8. Rhythms
  • 9. Life in the Fast Lane
  • 10. The Human Computer
  • 11. Outsmarting the Hungry Brain
  • Acknowledgments
  • Notes
  • Index
  • About the Author

Three key takeaways from The Hungry Brain

1How our brains drive food cravings

In Stephan J. Guyenet’s book, The Hungry Brain, an eye-opening revelation emerges: dopamine, often linked with pleasure, functions primarily as the ‘learning chemical’ that strengthens sensory cues. This revelation challenges conventional wisdom. Our brains possess an innate drive to seek high-calorie foods, a behaviour deeply ingrained even when we’re not hungry, courtesy of the subconscious mind. Guyenet posits that addiction represents an intensified version of the reinforcement process inherent in all of us. To mitigate excessive calorie consumption and combat the infamous ‘buffet effect,’ the author suggests a practical approach of limiting food variety, especially in environments like buffets or social gatherings. Furthermore, the book delves into the critical factors – variations in food reinforcement value, impulsivity, and exposure to enticing foods in one’s surroundings – that underpin why some individuals develop obesity while others remain unaffected.

2Leptin plays a crucial role in appetite regulation

The author delves into the complex mechanisms of appetite regulation within our bodies. Among the key components in this intricate system is the lipostat, predominantly located in the hypothalamus, which plays a pivotal role in determining our sensation of fullness. When individuals experience systematic underfeeding and subsequently regain their usual dietary habits, they often encounter a heightened appetite, particularly as they approach their initial body weight. These fluctuations in appetite are closely linked to the hormone leptin, with individuals suffering from leptin deficiency, such as obese children, demonstrating insatiable hunger. Leptin injections have proven beneficial for these children, although their efficacy in individuals with normal leptin levels remains inconclusive.

Guyenet postulates that as individuals gain weight, leptin’s function in regulating adiposity undergoes alterations, partly due to the lipostat adapting to an unfamiliar environment. Various factors, including the palatability of one’s diet, hunger signals originating from the hypothalamus, food rewards, and physical exercise, can impact the lipostat’s operation. For instance, exercise may have a dual effect by stimulating appetite through fat loss while potentially lowering the lipostat’s set point, thus reducing hunger. This inherent variability may elucidate the mixed outcomes observed in studies investigating the influence of exercise on weight loss.

3The role of ancient instincts in modern overeating

In The Hungry Brain, we uncover the fascinating link between our ancient instincts and modern overeating habits. The very brain that once drove our hunter-gatherer ancestors to seize calorie-rich foods for survival now compels us to overindulge in our modern, affluent world. While prioritising present needs over future well-being made sense in a hazardous ancestral environment, today’s stable conditions call for valuing our future selves.

An effective strategy Guyenet suggests is ‘episodic future thinking,’ where we envision ourselves in the future before making choices. This mental exercise prompts our brains to weigh future consequences more heavily during decision-making, helping us make healthier choices. The book challenges the conventional belief that obesity solely results from voluntary overeating, asserting that genetic differences make some individuals more vulnerable to the environmental shifts that have led to the significant increase in obesity rates, particularly in the 20th century.

Strengths and weaknesses, according to readers’ reviews


  • Informative and backed by mainstream scientific research on weight loss.

  • Provides a deep understanding of the brain’s role in weight management.

  • Presents complex biological concepts in an accessible and reader-friendly manner.

  • Offers a comprehensive view of the breakdown in natural biological systems and feedback loops contributing to overconsumption of calories.


  • Lacks significant new insights or information for readers already well-versed in the subject matter.

Best quotes from The Hungry Brain

“Again, it seemed as if the diets were not just passively causing weight gain but actually changing the set point of the lipostat.”

“Although 116 pounds is an impressive amount of weight to lose, at the end of the weight-loss period, the volunteers were still considered to have obesity. Remarkably, after weight loss, the number of calories their bodies consumed was only about three-quarters of what it should have been based on their new, slimmer body size. What’s more, they were ravenously hungry. Something was shutting down their metabolic rate and ramping up their appetites – fighting their weight loss – even though they remained quite fat.”

“The third most influential factor Holt and colleagues identified is a food’s fat content. The more fat it contained, the less filling it was per calorie. People often find this counterintuitive, because when they eat high-fat foods, they feel extremely full. The key to understanding this is to remember that we’re talking about fullness per unit calorie. If you eat a stick of butter, you may feel full, but you will also have eaten over 800 Calories – the equivalent of two and a half large baked potatoes. Isolated fats like butter and oil are the most calorie-dense substances in the human diet by far, mostly because fat delivers nine Calories per gram versus only four for carbohydrate and protein. Isolated fats also increase the palatability of food.”

Final takeaway

Stephan J. Guyenet’s The Hungry Brain offers an enlightening journey into the intricate world of weight management, exploring the profound impact of our brains, genetics, and environment on our eating habits. Guyenet adeptly conveys complex biological concepts in an accessible manner, making it suitable for a wide range of readers. By shedding light on the breakdown of natural biological systems that contribute to the overconsumption of calories, Guyenet provides valuable insights into the mechanisms behind weight gain. While it may not offer groundbreaking revelations for those already well-versed in the subject, it serves as a comprehensive and scientifically sound resource for anyone on a quest for a healthier lifestyle.

Where to buy

You may purchase The Hungry Brain on Amazon at the best price. It is available in paperback, hardcover, audio and Kindle versions, so you may choose an option that appeals to you the most.

Healthypedia FAQ

Yes, even if you're new to the subject, The Hungry Brain is written in a manner that makes complex scientific concepts accessible. Stephan J. Guyenet does an excellent job of explaining intricate biological processes in a reader-friendly way, ensuring that newcomers can grasp the core ideas.

The Hungry Brain is a trustworthy source of information that relies on mainstream scientific research on weight management. Stephan J. Guyenet presents a comprehensive view of the subject without promoting a particular diet or approach. The book is based on scientific evidence rather than advocating for a specific weight loss method.

The Hungry Brain primarily focuses on providing scientific explanations for the mechanisms that govern our eating habits and weight management. While it offers valuable insights into the brain's role in weight regulation, it may not serve as a step-by-step practical guide for weight loss. However, the knowledge gained from the book can inform healthier dietary choices and lifestyles how would you describe this book in one short sentence decisions.

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