Lillian Wilson

Powerhouse by Greg Wells

Greg Wells' book ‘Powerhouse’ outlines accessible methods to revitalize mitochondria and bring your health and energy to the next level.


The book has gotten 3.5 ⭐️ on GoodReads.

Have you ever thought about the fact that every six months, 98% of the cells in your body are actually brand new? It is like having a fresh brain and body twice a year! What makes this renewal possible are mitochondria – little energy powerhouses inside your cells.

In this review, we will take a closer look at the book ‘Powerhouse’ by Greg Wells. The read reveals simple yet revolutionary techniques for rejuvenating the mitochondria, thus revitalising our entire being. With a staggering 45% of the North American population struggling with chronic fatigue, the importance of this energetic renaissance becomes abundantly clear.

Author’s background

Greg Wells, Ph.D., is a performance physiologist who conducts research in translational medicine at the Hospital for Sick Children.

Greg Wells (r)

Furthermore, he holds the position of CEO at Wells Performance, a worldwide consulting enterprise. Notably, he has authored books such as ‘The Ripple Effect: Rest, Refocus, Recharge’ and ‘Superbodies.’ Wells is highly in demand as a speaker and consistently contributes to various international media outlets like the Globe and Mail, CBC, CTV, and TSN, along with numerous newspapers and magazines. He resides in Toronto with his family.

What is the book about?

In ‘Powerhouse,’ Greg Wells presents innovative methods to rejuvenate mitochondria, the energy centres of cells, leading to improved overall well-being. These approaches, such as simple breathing exercises, targeted supplements, and avoiding detrimental technology, restore and enhance the body’s functions, resulting in reduced fatigue, better moods, and hormonal health.

Backed by groundbreaking science and Wells’s own research at the Hospital for Sick Children, ‘Powerhouse’ provides practical advice to elevate the health of every cell. The book highlights the critical role of mitochondria in health and disease, including conditions like Alzheimer’s, autism, and cardiovascular issues, underlining the importance of maintaining optimal mitochondrial function.

The book concludes by elucidating the 100-Day Mitochondrial Challenge which offers readers a structured plan for the transformation of their mitochondria through proactive measures.

Table of contents

  • Introduction An Upward Spiral of Wellness
  • Breathe: Breath, Oxygen, and the Source of Energy for Life
  • Move: Movement, Optimal Health, and Exponential Wellbeing
  • Energize: Healing, Fuel, and Power for Sustainable Human Energy
  • Thrive: Crafting Your Life of Health, Wellbeing, and Performance
  • The 100-Day Mitochondrial Challenge: A Simple Daily Plan for a New You
  • Acknowledgements
  • Notes
  • Index
  • About the Author
  • Also by Greg Wells
  • Copyright
  • About the Publisher

Three key takeaways from ‘Powerhouse’

1Breathwork fuels mitochondria

In ‘Powerhouse,’ Greg Wells emphasises the profound impact of breath control on our overall well-being and performance. Breathing fuels mitochondria – the cellular powerhouses that drive our body’s energy production.

Research reveals that breathwork can yield numerous benefits, including reduced stress, improved concentration, enhanced creativity, and relief from anxiety and depression. As we engage in deliberate breathwork practices, we create a favourable environment for mitochondria to produce adenosine triphosphate (ATP), the energy currency of our bodies. Oxygenating mitochondria through breath improves cognitive, emotional, and physical performance.

Understanding the connection between breath and mitochondria empowers us to optimise our well-being. It’s important to approach breathwork with caution, avoiding overexertion to prevent potential risks. Consulting a professional and gradually incorporating breathwork into our routines can lead to remarkable enhancements in energy, focus, relaxation, and overall life satisfaction.

2Regular physical activity optimises mitochondrial health, leading to an extended lifespan

Mitochondria play a pivotal role in ageing, and their dysfunction is a hallmark of the ageing process. While genetic factors contribute to ageing, we have the power to optimise cell and mitochondrial health to extend our lifespan and enhance our well-being.

Physical movement emerges as a potent stimulus to promote mitochondrial health. Regular physical activity not only triggers the creation of new mitochondria but also enhances their size, density, and enzymatic activity. It is encouraging that even modest activity levels yield significant benefits. Studies show that taking over 7,000 steps daily reduces mortality risk by 50% to 70%, and engaging in a variety of leisure activities can substantially enhance overall longevity.

Mitochondrial health can improve remarkably in as little as 10 days of consistent movement, resulting in increased enzyme activity that fuels energy production. While initially, exercise might induce fatigue, persistence leads to improved well-being, strength, and overall ease in daily tasks. The transformative effects of consistent movement extend beyond physical benefits to enhance cognitive, emotional, and professional aspects of life. All this will later contribute to one’s ageing and defy how much the process affects our health and well-being.

3Moderate stress promotes mitochondrial health

The author acknowledges the ongoing problem of chronic stress and burnout that affects nearly 45% of the North American population. Wells suggests that the issue can be tackled by focusing on boosting energy at the cellular level by taking care of our mitochondria. When our mitochondria do not function well due to too many reactive oxygen species (ROS) and oxidative stress, it adds to the stress crisis. If ROS levels are too high, they can harm our mitochondria and make us feel drained. On the flip side, lower levels of ROS can actually trigger our body to respond in helpful ways, leading to more energy and better health. Surprisingly, even though we often think of ROS as harmful, they also have an important role in signalling when they are not at harmful levels, contributing to our body’s natural processes.

Activities that give us a bit of stress, like exercise, eating fewer calories, experiencing temporary low oxygen levels, or brief temperature changes, can actually be good for us at the cellular level and promote health. Our body’s inflammatory response and ROS are connected in a two-way relationship: chronic stress leads to inflammation, but exercise can release helpful anti-inflammatory substances. These substances activate pathways that boost antioxidants, which are good for our mitochondria and overall health. The main idea here is that moderate stress is actually good for our mitochondria, promoting their growth, health, and giving us more energy to protect against burnout.

Strengths and weaknesses, according to readers’ reviews


  • Presents comprehensive information well-supported by science and the author’s experience as a physiologist.

  • Establishes an ideal balance between the scientific and practical sides of the topic.

  • Provides a wide range of practices to improve mitochondrial health, from breathwork to intermittent fasting.

  • Written in an accessible and reader-friendly language.


  • The way mitochondria react to various strategies can differ a lot from person to person because of genetics, environment, and lifestyle. The book does not cover this variation thoroughly, which could result in different outcomes for different readers.

Best quotes from ‘Powerhouse’

“Almost all our human cells (except for red blood cells), whether brain, muscle, bone, or skin, have mitochondria powering them. Nearly every other life form on the planet also has mitochondria powering its cells. As your science teacher said, mitochondria are the cellular powerhouse of all life on the planet.”
“Movement is perhaps the most powerful stimulus to build and strengthen our mitochondria.”
“Approximately 45% of the North American population is chronically fatigued, and this fatigue is associated with increased risk of developing many mental and physical diseases.”

Final takeaway

Greg Wells’s book ‘Powerhouse’ offers a timely and practical guide for individuals seeking to optimise their well-being and vitality by focusing on the health of their mitochondria. With his background as a performance physiologist and his research at the Hospital for Sick Children, Wells presents a compelling case for the pivotal role of mitochondria in overall health. By emphasising the significance of breathwork, physical activity, and even moderate stress, Wells provides readers with actionable strategies to enhance their mitochondrial function and, consequently, their energy levels, cognitive performance, and emotional well-being.

‘Powerhouse’ is highly recommended for those interested in harnessing the transformative potential of their cellular energy for a more vibrant and resilient life.

Where to buy

You may purchase ‘Powerhouse’ on Amazon at the best price. It is available in paperback, audio and Kindle versions, so you may choose an option that appeals to you the most.

Healthypedia FAQ

Absolutely! By following the methods Greg Wells shares in the book, we can help our body and mind feel better. Better energy levels, improved mood, and even better hormonal health are some of the benefits that come from taking care of our mitochondria.

Yes, the book is backed by solid scientific research. Greg Wells, being a performance physiologist, includes evidence and studies to support the effectiveness of the strategies he suggests.

The book is written in a reader-friendly language that's easy to understand. Greg Wells breaks down complex concepts into simple explanations that anyone can grasp.

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