Lillian Wilson

The TIGER Protocol by Akil Palanisamy

This book is a comprehensive guide for managing autoimmune conditions through holistic approaches and practical tools.

The TIGER Protocol

The book has received 4.2 ⭐️ on GoodReads.

Autoimmune diseases, a complex group of conditions wherein the immune system mistakenly attacks the body’s own tissues, have become increasingly prevalent in today’s health landscape. These disorders, which encompass a wide range of conditions such as rheumatoid arthritis, lupus, and multiple sclerosis, can have a profound impact on individuals’ lives, often requiring long-term management and care. In the quest for effective strategies to combat autoimmune diseases, a comprehensive understanding of their root causes and holistic treatment approaches is paramount.

Fortunately, there exists a promising resource that delves deep into these matters – The TIGER Protocol: An Integrative, 5-Step Program to Treat and Heal Your Autoimmunity by Dr. Akil Palanisamy. In this review, we will explore the book’s insights, strengths, and weaknesses, shedding light on its potential to empower individuals in their battle against autoimmune conditions.

Author’s background

Akil Palanisamy, MD, is a Harvard-trained physician specialising in integrative medicine, combining conventional medical knowledge with holistic approaches like functional medicine and Ayurveda.

Akil Palanisamy, MD (r)

He holds a magna cum laude Bachelor of Arts in biochemical sciences from Harvard University and earned his MD from the University of California, San Francisco (UCSF). Currently, Dr. Akil serves as the Department Chair for Integrative Medicine at the Sutter Health Institute for Health and Healing (IHH).

What is the book about?

The TIGER Protocol by Akil Palanisamy is a groundbreaking book that provides a comprehensive and holistic approach to addressing autoimmune diseases. Dr. Palanisamy has developed the TIGER Protocol, an acronym that stands for Toxins, Infections, Gut Health, Eat Right, and Rest. This protocol outlines the key root causes that should be tackled to prevent or reverse autoimmune conditions.

The book emphasises the importance of addressing these factors in a specific order for optimal results. Divided into three parts, the book covers the following topics:

  • The immune system and its dysfunction in autoimmune conditions.

  • Five root causes of autoimmunity and the factors contributing to the rise in autoimmune disorders.

  • Practical guidance on implementing the TIGER Protocol, including detoxification, infection identification and treatment, gut-healing protocols, and proper rest techniques.

  • Herbs, botanicals, vitamins, compounded medications, and natural therapies that can help ‘reboot’ the immune system.

The TIGER Protocol is not just about managing symptoms; it aims to help individuals achieve health and reduce flare-ups, attain remission with minimal medication, and live life to the fullest by providing a holistic approach to addressing autoimmune conditions. Dr. Akil Palanisamy’s book empowers readers with the knowledge and practical tools to take control of their health and well-being.

Table of contents

  • Introduction
  • Part One: Understand the TIGER Protocol
  • Chapter 1: Overview – Immune Systems Gone Haywire
  • Chapter 2: Toxins – The Missing Puzzle Piece
  • Chapter 3: Infections – Disrupting Immune Balance
  • Chapter 4: Gut – The Foundation of (Immune) Health
  • Chapter 5: Eating – Food Sensitivities and the Phase 1 Diet
  • Chapter 6: Rest – Understanding Mental and Emotional Rest and Your Nervous System
  • Part Two: Implement the TIGER Protocol
  • Chapter 7: Toxins – Detoxify and Improve Liver Function
  • Chapter 8: Infections – Identify and Eliminate Infections
  • Chapter 9: Gut – Healing Your Gut (and Oral) Microbiome
  • Chapter 10: Eating – Prebiotic Foods and the Phase 2 Diet
  • Chapter 11: Rest – Tools for Optimizing Rest
  • Part Three: Reach the Next Level of Health
  • Chapter 12: Modulate the Immune System
  • Chapter 13: What to Do If You’re Not Getting Better
  • Chapter 14: Putting It All Together – Nutritional Supplements and Next Steps
  • Conclusion
  • 14-Day Meal Plan
  • TIGER Protocol Recipes
  • Acknowledgments
  • Discover More
  • Notes
  • About the Author

Three key takeaways from The TIGER Protocol

1Detoxification is crucial for improving health, especially for autoimmune conditions

In The TIGER Protocol, the significance of detoxification in improving overall health and its profound impact on autoimmune diseases take centre stage. The author emphasises the critical role of detoxifying the body, particularly through optimising digestive function and daily elimination. The book explores the body’s detox pathways, including the liver, skin, and lymphatics, and provides valuable insights into enhancing detoxification capacity through dietary choices, spices, herbs, and supplements.

What sets this book apart is its compelling real-life examples, demonstrating how detoxification can positively influence autoimmune conditions. By sharing cases of individuals experiencing relief from conditions like rheumatoid arthritis and multiple sclerosis through detoxification methods, the author underscores the protocol’s importance.

Furthermore, the book underscores the significance of regular bowel movements, the role of fibre in detox, and key clues that hint at suboptimal liver function. The author also delves into the practice of detoxification through sweating, particularly in saunas, and how it can help eliminate heavy metals and environmental toxins. Finally, the book provides practical dietary recommendations, including superfoods like beets, cruciferous vegetables, garlic, and chlorella, to aid in daily detoxification. With this comprehensive guide, readers gain essential knowledge on detoxification’s pivotal role in addressing autoimmune diseases and achieving better health.

2Gut health plays a central role in dealing with autoimmune conditions

In The TIGER Protocol, Dr. Akil Palanisamy emphasises the significance of gut health and its pivotal role in addressing autoimmune conditions. The book outlines a four-week program dedicated to healing and strengthening the gut, essential for restoring the body’s immune system regulation. The author discusses methods for assessing intestinal permeability, highlighting biomarkers like zonulin, the lactulose/mannitol ratio, and serum lipopolysaccharide.

Dysbiosis, a common cause of increased intestinal permeability in autoimmune patients, is addressed, along with dietary recommendations, including the importance of fibre intake, prebiotic fibres like inulin, bone broth, collagen, omega-3 fats, zinc, fermented foods, and intermittent fasting. Supplements such as curcumin, glutamine, colostrum, and probiotics are also explored, with a focus on selecting the right probiotic strains to meet specific goals.

Overall, the book underscores the vital role of diet and supplements in healing and improving intestinal permeability, offering valuable insights for readers seeking to manage autoimmune conditions through gut health optimisation.

3Mindfulness practices are a powerful tool for managing autoimmune conditions

Stress is a significant factor in the development and exacerbation of autoimmune conditions. It triggers a cascade of responses in the body that lead to increased inflammation and autoimmune activity. Addressing stress through mindfulness and meditation can have numerous positive effects on both mental and physical well-being.

Regular meditation not only reduces stress but also positively impacts inflammation, the gut barrier, and the immune system. It can even lead to structural and functional changes in the brain. Incorporating meditation into daily life, even for just a few minutes a day, can be a powerful tool for managing autoimmune conditions and promoting overall health.

Strengths and weaknesses, according to readers’ reviews


  • Offers a comprehensive approach to managing autoimmune conditions, providing a step-by-step guide for readers.

  • Effectively integrates conventional and alternative medicine, catering to a broad range of treatment preferences.

  • Emphasises individualisation, recognising that each person’s healing journey is unique.

  • Dr. Akil’s expertise and caring nature shine through the pages, making the book both informative and empathetic.

  • Readers find the book highly informative and well-structured, with an overwhelming amount of information presented in an easily digestible format.


  • While the book is praised for its content, the quality of the recipes may leave room for improvement.

  • A few readers mentioned that they found the coconut flatbread recipe problematic, suggesting it may need revision.

Best quotes from The TIGER Protocol

“Research shows that using a sauna four to seven times per week led to a 40 percent reduction in death from all causes over a 21-year time period (using it two to three times per week was associated with a respectable 24 percent decrease).”
“Pesticides have been linked to various autoimmune conditions, multiple types of cancer, and other health problems; the CDC has determined that 93 percent of Americans tested had detectable levels of the insecticide chlorpyrifos and 99 percent had detectable levels of DDT, with the average person carrying about thirteen pesticides. This is concerning because the CDC tests for only a fraction of the total number of pesticides to which we are exposed, but still found that a significant number of people tested had potentially harmful body levels of certain pesticides above government safety thresholds.”
“Thus, for millennia, our ancestors evolved eating a diet that was much higher in fiber and prebiotics, and that is what our microbiota evolved to expect. This was likely the key factor in the robustness and diversity of the ancestral microbiome. As the intake of fiber has plummeted over the past 200 years, the food that our bacteria relied on has disappeared. The consequences are serious.”

Final takeaway

The TIGER Protocol by Dr. Akil Palanisamy is an invaluable resource for individuals seeking a holistic approach to managing autoimmune conditions. Dr. Palanisamy’s comprehensive protocol, blending conventional and alternative medicine, empowers readers to take control of their health and address the root causes of autoimmune diseases. The book excels in educating readers about the pivotal role of detoxification, the importance of gut health, and the power of mindfulness practices in achieving well-being.

Anyone looking to embark on a healing journey to manage autoimmune conditions should consider reading this book to gain insights, knowledge, and tools for better health.

Where to buy

You may purchase The TIGER Protocol on Amazon at the best price. It is available in paperback, hardcover, audio and Kindle versions, so you may choose an option that appeals to you the most.

Healthypedia FAQ

Absolutely. The TIGER Protocol is designed to be accessible and informative for newcomers. Dr. Akil Palanisamy provides a step-by-step approach, making it easy for readers to understand the complexities of autoimmune diseases and holistic treatment options. The book's structure and clear explanations ensure that even those with limited prior knowledge can navigate its content effectively.

Dr. Akil Palanisamy's extensive background in integrative medicine, including his Harvard education and experience as the Department Chair for Integrative Medicine at the Sutter Health Institute for Health and Healing, lends a high level of trustworthiness to the book. Additionally, the book is well-researched, with information backed by scientific evidence and real-life examples, further solidifying its reliability.

Yes, The TIGER Protocol goes beyond theory and offers practical tools and actionable advice. Whether it is guidance on detoxification, dietary recommendations, or suggestions for managing stress, the book provides readers with tangible steps they can incorporate into their daily lives.

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