Lillian Wilson

Regenerate by Sayer Ji

‘Regenerate’ goes beyond conventional medical beliefs and reveals an alternative approach to health and ageing.

‘Regenerate’ by Sayer Ji; A Book Review

The book has gotten 4.15 ⭐️ on GoodReads.

The world of science is brimming with evolving insights and revolutionary perspectives, and the boundaries of traditional understanding are continually pushed. Such is the case with ‘Regenerate’ by Sayer Ji, a book that seeks to transform our perception of health, ageing, and the intricate interplay between our genetic makeup, lifestyle choices, and the environment.

In this review, we embark on an exploration of ‘Regenerate’, delving into its revelations, strengths, and nuances, as it invites us to reevaluate our understanding of health and the body’s remarkable capacity for self-renewal.

Author’s background

Sayer Ji is the founder of GreenMedInfo, a leading open-access natural health database.

Sayer Ji (r)

He holds roles as a reviewer for the International Journal of Human Nutrition and Functional Medicine, co-founder and CEO of Systome Biomed, a board member of the National Health Federation, and a steering committee member of the Global Non-GMO Foundation.

What is the book about?

‘Regenerate’ by Sayer Ji introduces a new way of thinking about health and ageing. It changes the way we understand the body’s ability to heal itself. The book explores how tiny RNA messages in our bodies affect our health, from getting older to heart health, cancer, brain decline, and metabolic problems. Ji challenges the idea that our genes are the only things that decide our health. Instead, he shows how our choices and the environment we live in also play a big role.

The book is split into three parts. Part I, ‘Your Body and the Miracle of Regeneration,’ explains how our bodies and plants are connected, how genes work, and how our choices affect our health. Ji talks about microRNAs, important messengers in our food, and telomeres, parts of our DNA that affect ageing.

Part II, ‘Rethinking Chronic Disease, Prevention, and Healing,’ discloses how the Western Pattern Diet is linked to chronic conditions and faster ageing. Ji also talks about how our feelings and thoughts can affect how our cells get damaged and how the medical system plays a role.

Part III, ‘Regenerate Rx,’ provides a plan for better health. The plan is revolving around the idea of detoxification from the Western Pattern Diet and eating like our ancestors did. The author also suggests engaging in intentional movements, sleeping better, and reducing stress to help our bodies fix problems and stop diseases.

Table of contents

  • Introduction
  • Part I Your Body and the Miracle of Regeneration
  • The Truth About Your Genes, Food as Information, and Your Body’s Alchemical Physiology
  • Chapter 1 The New Biology Revolution DNA, MicroRNA, and the Gene Expression Connection
  • Chapter 2 Food as Information Living Water, Epigenetic Pathways, and the Wisdom of the Ancestral Diet
  • Chapter 3 The New Biophysics of Energy Synthesis How the Body Harvests Nature’s Alternative Energy Sources to Power Cellular Pathways, Build Resilience, and Promote Our Evolutionary Edge
  • Part II Rethinking Chronic Disease, Prevention, and Healing
  • The Role of Stem Cells in Regeneration
  • Chapter 4 Beyond Gene Mutation Cancer’s Origin, Prevention, Treatment, and Lifesaving Patient Empowerment and Resilience Strategies
  • Chapter 5 Lifestyle Medicine for Brain Health Toxicants to Avoid and Practices to Keep Your Mind Vibrant for Life
  • Chapter 6 Understanding Your Heart Myths and Facts about Medications, Cholesterol, Fat, and the Inflammation Connection
  • Chapter 7 Reversing Metabolic Disease Natural Remedies for Insulin Resistance, Belly Fat Accumulation, and Dietary Hormone Disruptors
  • Chapter 8 The New Ageing Paradigm How to Rewind Your Biological Clock
  • Part III Regenerate RX
  • A Four-Phase Program for Triggering Your Body’s Radical Resilience Mechanisms
  • Phase 1 Introduction Apples and Clean Water Mono Diet (1-3 days)
  • Phase 2 Re-entry Establishing Ancestral Diet Patterns (2 weeks)
  • Phase 3 Supplementation Nourishing Your Regenerating Body (2 weeks)
  • Phase 4 Mind/Body Healing Detox and Intentional Movement Techniques (for life)
  • Endnotes
  • Acknowledgments
  • Continue Your Journey with Hay House
  • About the Author
  • Index

Key takeaways from ‘Regenerate’

1DNA is not a blueprint for our health, our choices are

The book challenges the conventional notion of DNA as a strict blueprint for our health and disease. In Western medicine, diseases were often blamed on our genes, but ancient medical systems and Eastern cultures say it is more about how our bodies, the environment, and our choices work together. This shift is about moving away from just genes controlling everything to a new field called epigenetics.

Epigenetics reveals that genes are not solely responsible for our health. Beyond genes, special proteins and processes on them also matter, and our environment can switch genes on or off. Our choices, such as diet, activity, stress management, and relationships, shape gene behaviour. This perspective shifts from genes being everything to acknowledging our control over health through lifestyle and environment, as various diseases related to gene use, not just the genes themselves.

2To achieve health ourselves and ensure healthy offspring, we must embrace radical responsibility

The way genes work is getting a new twist with the discovery of microRNA/exosome genetic expression. Traditional beliefs centred on chromosomal inheritance through germline cells are being questioned as research indicates that traits influenced by lifestyle, experiences, and exposures can be transmitted across generations through somatic cells.

Things like pollution, heavy metals, pesticides, and things we do in our lives like smoking and feeling stressed can change how our genes work through epigenetics. But, we can fix this by using what nature gives us. Doing activities like exercise, being mindful, and eating healthy stuff from fruits and veggies can make our bodies stronger and more resistant.

Everything around us, from the air we breathe to the food we eat and how we think, matters for generations. Taking charge of this helps us make choices for our health and the health of those who come next.

3Microbiome plays a crucial role in all aspects of our health

‘Regenerate’ challenges the idea that microorganisms only cause disease and uncovers how the microbiome influences digestion, immunity, and well-being. The microbiome, composed of bacteria, viruses, fungi, and archaea, is an intricate ecosystem that dwarfs human cells in terms of genetic material, with 99.9% of our genes residing within it. The microbiome has a strong impact, controlling digestion, nutrient absorption, detoxification, immune function, and even neurotransmitter production. Some friendly bacteria even help break down toxins, showing how crucial they are for our health.

The microbiome’s importance is evident since birth. Natural birth and breastfeeding are key for creating a diverse and balanced microbiome, strengthening immunity and overall health. On the other hand, practices like C-sections and formula feeding can disturb the balance of microbes, leading to problems. Breast milk, rich in nutrients and gene-regulating microRNAs, supports the variety of microbes, showing how closely nutrition and microbiome health are linked.

Strengths and weaknesses, according to readers’ reviews


  • Challenges established scientific beliefs, offering a thought-provoking and eye-opening reading experience.

  • Authoritative and knowledgeable, Sayer Ji’s expertise shines through, especially in areas like cancer treatment and energy sources.

  • Accessible explanations of complex topics, although the vocabulary might be challenging for some readers.

  • Profound dietary insights are presented in a digestible manner, allowing easy incorporation into daily routines.


  • The selective use of research undermines the book’s credibility.

  • The book’s premise is intriguing, but the dense use of technical terms in the first half may deter some readers.

Best quotes from ‘Regenerate’

“In fact, certain foods and lifestyle practices can unlock immense self-regenerative energetic resources within your cells, optimizing DNA expression and making them more important in affecting your health than any other single factor.”
“A recent study published in Frontiers in Human Neuroscience demonstrated that while most forms of exercise slow down age-related decline, dancing has even more profound benefits. Considered a psychosocial intervention, dancing combines the mood-elevating effects of increased social interaction with improvements in brain function, cardiac fitness, and overall quality of life.”
“Also known as paleo-deficit disorder, evolutionary mismatch refers to the collective deficiency of ancestral influences in the modern, industrialized landscape. Paleo-deficit disorder runs the gamut from reduced opportunities for privacy and solitude to decreased tactile contact with a variety of natural vegetation to reduced exposure to birdsong, daylight, and phytoncides, the allelochemical, volatile organic compounds emitted by plants that give the forest its characteristic aroma.”

Final takeaway

‘Regenerate’ by Sayer Ji presents a transformative perspective on health and ageing, challenging traditional scientific beliefs. By unravelling the intricate connection between genetics, lifestyle, and the environment, the book advocates for a paradigm shift in how we approach well-being.

‘Regenerate’ is a thought-provoking read that empowers individuals to take control of their health and embrace a holistic approach to wellness. Anyone interested in reshaping their understanding of health, genetics, and their impact on future generations should consider reading this insightful work.

Where to buy

You may purchase ‘Regenerate’ on Amazon at the best price. It is available in paperback, audio and Kindle versions, so you may choose an option that appeals to you the most.

Healthypedia FAQ

‘Regenerate’ uncovers the link between human evolution, genetics, and health; the Western Pattern Diet's impact on health and questions the medical establishment's role; presents a roadmap for better health, emphasising diet, supplements, movement, sleep, and stress reduction.

Sayer Ji supports his arguments with a combination of scientific research, insights from the field of epigenetics, and examples of real-life health transformations, providing a comprehensive foundation for his claims.

The book challenges the prevailing notion that genes solely determine our health destiny. It introduces the concept of epigenetics, emphasising that genes are not the sole drivers of disease. Instead, it explores how our choices, environment, and lifestyle contribute significantly to our overall health.

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