Lillian Wilson

Mayo Clinic on Digestive Health by Sahil Khanna

‘The Mayo Clinic on Digestive Health’ is an authoritative guide on digestive issues and practical tips for maintaining optimal health.

Mayo Clinic on Digestive Health

The book has received 4.4 ⭐️ from readers on Amazon.

With approximately 40% of the global population grappling with chronic gastrointestinal problems, ranging from heartburn to irritable bowel syndrome, there is a critical need to shed light on the intricate web of factors influencing these concerns. Often rooted in elements such as dietary patterns, stress levels, medication use, and physical activity, digestive issues serve as potential indicators of deeper underlying matters within the gut.

This review focuses on the book ‘Mayo Clinic on Digestive Health’ authored by Sahil Khanna, which directly addresses the prevalent issue of digestive illnesses. As we navigate the contents of this book, we will explore its insights, guidance, and potential to illuminate the path toward better gastrointestinal well-being.

Author’s background

Sahil Khanna, M.B.B.S., holds the position of a gastroenterologist and internist at Mayo Clinic located in Rochester, Minnesota.

Sahil Khanna (r)

Within the Division of Gastroenterology and Hepatology, he leads the Comprehensive Gastroenterology Interest Group. Additionally, Dr. Khanna is an associate professor of medicine at Mayo Clinic College of Medicine. His research is centred around various areas including epidemiology, faecal microbiota transplantation, microbiome studies, and novel treatments and outcomes related to Clostridium difficile (C. diff.) infection. Dr. Khanna’s contributions have been acknowledged through multiple accolades such as the Miles and Shirley Fiterman Award, the Mayo Brothers Distinguished Fellowship Award, and the Most Distinguished Resident Physician Award by the American Association of Physicians of Indian Origin. He is currently serving as a fellow for the American College of Gastroenterology.

What is the book about?

‘Mayo Clinic on Digestive Health’ offers readers a clear and comprehensive exploration of the functioning of the digestive system. While the process of digestion may appear straightforward – intake, breakdown, absorption, and elimination – the reality is that the digestive system is a remarkably intricate network of organs that collaboratively process and transform food into vital nutrients essential for well-being.

Amidst this complexity, disruptions can arise, leading to a range of digestive issues. In its fourth edition, the book addresses an array of these issues, encompassing symptoms, causes, diagnostic methodologies, treatment choices, and even proactive measures for prevention. Whether you are struggling with temporary discomfort from common problems like heartburn, diarrhoea, constipation, or gas, or facing more pervasive conditions such as gastroesophageal reflux disease, peptic ulcers, gallstones, Crohn’s disease, or celiac disease, the book caters to a broad spectrum of readers seeking answers.

The book recognises the burgeoning understanding, early detection, and treatment options for various digestive ailments. It particularly highlights the emerging comprehension of the profound influence of the gut on overall health, particularly the pivotal role played by gut bacteria. This intricate interplay extends to interactions with other bodily systems, presenting an interconnected web of health.

Particularly concerning dietary choices, ‘Mayo Clinic on Digestive Health’ equips readers with accurate insights to make informed decisions. By contextualising the essentials of maintaining a healthy digestive system and outlining approaches to combat disease, the book serves as a valuable resource for those navigating the complexities of digestive health.

Three key takeaways from ‘Mayo Clinic on Digestive Health’

1Your gut matters

The significance of a healthy gut cannot be overstated, as it directly impacts overall well-being. Digestion, a vital bodily function, transforms ingested food into essential nutrients that fuel growth, repair, and maintenance. This intricate process involves breaking down food components and chemically altering them for absorption into the bloodstream, while waste is eliminated. Digestive juices and mechanical actions within the mouth, stomach, and intestines collaborate to facilitate this process.

However, disruptions within this complex system can occur, leading to various signs and symptoms that signal underlying issues. Heartburn, cramps, bloating, diarrhoea, and other distressing symptoms serve as warning signals, indicating that the digestive system is not functioning optimally.

The author emphasises that we should not normalise these problems and resort to over-the-counter drugs to alleviate some of the symptoms. 70% of your immune system resides in the gut, which means that if your gut suffers, it can make you more susceptible not only to infections but also to various chronic diseases.

2You thrive when your microbiome thrives

The gut microbiome plays a crucial role in overall health, encompassing the diverse microorganisms that inhabit the digestive system and their genetic components. This ecosystem varies between individuals and is influenced by factors such as birth methods, breastfeeding, diet, and ageing. Roughly 100 trillion gut microorganisms, consisting of various bacterial species, contribute to functions like digestion, nutrient absorption, metabolism regulation, and immune system modulation.

An imbalance in gut microbiota, known as dysbiosis, can result from factors like diet. Westernised diets rich in fast foods and sugars, while low in fibre, fruits, and vegetables, have been linked to an increased incidence of diseases such as obesity, cancer, and inflammatory conditions. Dietary choices, including excessive consumption of saturated fats and artificial sweeteners, can alter gut microbial composition, leading to inflammation and potential health issues. Conversely, plant-based, high-fibre diets like the Mediterranean diet support gut diversity and health. Understanding the dynamic interplay between the gut microbiome and various lifestyle factors underscores the importance of maintaining a balanced and nourishing diet for overall well-being.

3Constipation is more than an inconvenience and can lead to serious complications

The book deals with symptoms and treatment strategies of various digestive diseases. In this review, we will take a look at a very common, yet overlooked condition – constipation. Chronic constipation affects a significant portion of adults, particularly women and older individuals. Severe cases can hinder daily life and social interactions, making medical attention crucial.

Several factors can cause constipation, including dietary and lifestyle imbalances, irritable bowel syndrome (IBS), pelvic floor dysfunction, medications, slow transit, and structural issues. Making small changes can be beneficial: increasing fibre intake, staying hydrated, exercising regularly, adhering to a bowel routine, and listening to your body’s urges.

Ignoring constipation can lead to complications like haemorrhoids and anal fissures. Hemorrhoids and anal fissures can lead to complications such as bleeding, pain, and infection, which can significantly impair a person’s quality of life and require medical intervention. What is more, constipation can affect the health of the thyroid gland which can lead to hormonal imbalance.

Strengths and weaknesses, according to readers’ reviews


  • Provides beneficial advice from a reputable source, being a Mayo Clinic publication.

  • Offers practical advice and recipes for healthy digestion.

  • Well-written with practical advice that proves highly helpful.


  • The content of the book appears rather dry and could be enhanced by incorporating success stories from the author’s patients.

Best quotes from ‘Mayo Clinic on Digestive Health’

“Good health and a healthy gut go hand in hand. Digestion is one of the critical functions your body must perform in order to survive and thrive. The food you eat provides necessary nutrients that supply your cells with sustenance and energy so your body can develop, repair and maintain itself.”
“More than 60 million Americans experience heartburn at least once a month, and more than 15 million may have heartburn daily.”
“What you put on your plate has a lot to do with good digestion. But it’s not only what you eat that’s important. How much you eat, and the manner in which you eat – relaxed or hurried, focused or distracted – also play key roles. Your daily food choices and eating habits go a long way toward keeping your digestive system strong and healthy.”

Final takeaway

‘Mayo Clinic on Digestive Health’ serves as a comprehensive guide to navigating the complexities of digestive well-being, offering valuable insights into maintaining a healthy gut. Authored by Dr. Sahil Khanna, a distinguished gastroenterologist from Mayo Clinic, the book covers a wide range of digestive issues and provides practical solutions. With a focus on the intricate interplay between diet, lifestyle, and the gut microbiome, the book empowers readers to make informed choices for their health.

This book is recommended for anyone looking to enhance their knowledge of digestive health and make informed decisions regarding their well-being.

Where to buy

You may purchase ‘Mayo Clinic on Digestive Health’ on Amazon at the best price. It is available in paperback, hardcover, audio and Kindle versions, so you may choose an option that appeals to you the most.

Healthypedia FAQ

Yes, Dr. Khanna's background and contributions ensure that the information provided in the book is reliable, evidence-based, and aligned with the current medical understanding of digestive health.

Yes, the book is written in a reader-friendly manner, making it accessible to individuals with various levels of medical knowledge. It avoids overly technical language and provides clear explanations, making it a useful resource for anyone interested in learning more about digestive health.

Yes, the book offers practical advice and strategies for managing and even preventing digestive issues. It provides insights into lifestyle changes, dietary modifications, and other measures that can help alleviate symptoms and improve digestive health.

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